STUDIES ON MAMMALIAN HISTIDINE DECARBOXYLASE
نویسندگان
چکیده
منابع مشابه
Mammalian histidine decarboxylase: from structure to function.
Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and highly prevalent pathologies. Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity (EC 4.1.1.22), an enzyme that still remains to be fully characterized. Nevertheless, during the last few years, i...
متن کاملHistidine decarboxylase in Enterobacteriaceae revisited.
With a modification of Taylor's decarboxylation broth, histidine decarboxylase was detected in Enterobacter aerogenes, Morganella morganii, Raoultella ornithinolytica, and some strains of Citrobacter youngae and Raoultella planticola. This method provides a useful confirmatory test for identification of E. aerogenes strains.
متن کاملHistidine Decarboxylase in Hyaline Membrane
During the latter part of pregnancy, the foetal rat produces large quantities of histamine which may be concerned with the growth of the foetus (Kahlson and Rosengren, 1959). Kahlson (1960) reported increased formation of histamine by the human foetus as well: recently Davis (1961) suggested that the antagonism of such excess histamine might account for the beneficial effect of an antihistamine...
متن کاملA Rapid Histidine Decarboxylase Assay1
Histidine decarboxylase (EC 4.1.1.22) catalyzes the conversion of histidine to histamine. Because current assays for enzyme activity are time consuming and require additional enzymes or large amounts of tissue, a rapid radioisotopic assay was devised. Using commercially available radioactive histidine (without additional purification), the enzyme mediates the formation of histamine. The product...
متن کاملThe pest regions containing C-termini of mammalian ornithine decarboxylase and histidine decarboxylase play different roles in protein degradation.
Proteasome 26S must recognize the PEST region-containing C-terminus of mammalian ornithine decarboxylase (ODC) monomer to proceed with degradation. We have detected PEST regions in both termini of mammalian histidine decarboxylase (HDC). In the present report, a chimaeric ODC/HDC was used to elucidate whether the PEST region-containing C-termini of ODC and HDC are exchangeable. Wild-type rat OD...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1956
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1956.tb01039.x